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parkinson disease
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Glossary


Acetylcholine

Chemical substance (neurotransmitter) released by cholinergic nerves. Acetylcholine is involved in many different brain functions, including control of motor activity. It is also associated with defined syndromes of Parkinson’s disease such as tremor and rigidity.

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Action tremor

Involuntary movement of limbs that occurs when limbs are moved voluntarily.

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Activities of daily living (ADL)

A rating scale to measure how important activities of daily living are impaired by Parkinson’s disease. The categories include speech, salivation, swallowing, handwriting, cutting food and handling utensils, dressing, hygiene, turning in bed and adjusting bedclothes, falling, freezing when walking, walking, left- and right-sided tremor, and sensory complaints.

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Adrenalin

Chemical substance (neurotransmitter) released by neurons of the sympathetic nervous system with usually activating functions.

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Adrenergic

Related to or controlled by the neurotransmitter adrenaline.

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Adjunctive treatment

Additional or auxiliary treatment to primary drug.

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Agonist

Chemical substance or drug that enhances or mimics the activity of a neurotransmitter, for example dopamine.

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Akinesia

Complete loss of ability to move, sometimes referred to as freezing.

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Amantadine

Chemical substance used in the treatment of Parkinson’s disease to improve tremor, rigidity and bradykinesia.

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Antagonist

Chemical substance or drug that reduces the activity of a neurotransmitter, for example dopamine.

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Anticholinergic agents

Chemical substances that inhibit or antagonize the effect of acetylcholine.

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Anxiolytic

A drug which reduces anxiety.

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Apomorphine

Chemical substance used in the treatment of Parkinson’s disease, especially to treat “off-times”. It is administered as a continuous subcutaneous infusion or as a subcutaneous injection.

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Antioxidant

Substance that prevents reactions of sensitive molecules with oxygen or other oxidizing chemicals.

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Apoptosis

„Programmed cell death“, usually a normal process in body tissues to give place for new cells. Some scientists claim that in Parkinson’s disease certain nerve cells seem to develop an abnormal high rate of apoptosis.

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Ataxia

loss of balance.

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Athetosis

Type of dyskinesia characterized by specific involuntary movements of hands and feet.

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Autonomic nervous system

also known as vegetative nervous system, responsible for controlling involuntary body functions.

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